>>2077621your soft tissue has gotten re-sensitized while you were off the bike. this much is true. just gotta tough it out for a month or whatever and it'll desensitize again.
your saddle may need adjustment.
saddle height is the most significant key to overall fit. also, is it level? does the nose stick up or down more than the rear? how forward or aft in the clamp it is can be a factor but usually that's the last position I dial in since it's the least significant ime.
a different saddle could help. or hurt. sounds like you were ok with it before so maybe you will be again. the width compared with your sitbone width is the most significant factor, which is also dependent on your riding stance. this chart corresponds to this particular mfr. but you get the overall idea.
the real answer is you just have to try a bunch of saddles, unfortunately.