>>3306877It sort of depends on what you want out of a camera, but in terms of photo quality, yes.
I have a Bronica 6x4.5 camera, which is on the small end of MF, but the step up from 35mm is pretty significant. Once you get into 6x7 and 6x9, the difference is huge, but so are the cameras.
This is some expired Ektachrome I shot with my Bronica.