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I'd like a slice-of-life style deal with Jessie and James.
>James is gay
Nigga you gay.
Story-wise, it doesn't really need to focus on pokemon or the world at large in general. That would be the set dressing instead of the focus with the real drama being something along the lines of-
>Life after team rocket
>raising kids
>interpersonal conflict around Jessie being from a poor background and James being from a rich one, and something to do with their family ties trying to break them up.