>>909034285 has fewer systems to learn and has more mods. With the last dlc, gameplay's focused on "tall" style, or less buildings, so it's easier to micromanage as a beginner.
6 is 64bit, has an easier time enabling/disabling mods, but the art style and UI is questionable albeit fixable via mods. There' alot more systems to learn, some which i like or dislike, and is focused on wide gameplay.
I play it with the touhou portrait system and civ 5 environment skin 