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On 2 October, when Colonel Rimfire, at the Looney Club in London, announces his beliefs that cats are the most intelligent, musical animals (after his many plans were foiled by Cool Cat), Granny, hoping to raise money for a nearby children's park that closes in 80 days, makes a wager that her Tweety can fly around the world in 80 days, collecting the pawprints of 80 cats in the process. Sylvester, still hoping to make Tweety his personal snack, is incensed at the thought of some other cat minions getting the little bird first. He vows to follow Tweety around the world and catch the canary himself; unbeknownst to either one, a thief is also present.
Tweety sets a course to Paris, but is blown by a strong wind to the Swiss Alps, where he gets trapped, as does Daffy Duck, but Bugs Bunny saves them both. He goes back to Paris, this time successfully and outsmarts Penelope Pussycat, where he causes Pepé Le Pew to mistake Sylvester for a female skunk. Tweety continues on to Venice, but grows overweight after eating too much bird seed. On a longboat, he faces a lot of cats, but he overpowers them and goes back to his normal size. While attempting to sleep in Egypt, he is chased into a tomb by Sylvester and his minions, but he escapes. Sylvester disguises himself as a dancing woman in a basket and takes it off as he catches Tweety, but when he sees hieroglyphics, Sylvester thinks he just sees images. A mummy cat army beats Sylvester as Tweety resumes to his escape. In the African jungle, he outsmarts Pete Puma and a lion with help from the Minah Bird.