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They're just really annoying and dark. Stuff like Family Guy or south park just depress me. I hate seeing these cute characters talk about fucked up stuff, and they usually get brutally murdered in over-the-top gory scenes that are supposed to "funny", but don't requre any comedic talent, just a pretentious animator trying to make shit that's shocking and unsettling.
Sometimes it's okay, like the Simpsons, but most adult cartoons have some strange, unsettling art-style that's just dirty and unwelcoming. I remember not really wanting to watch any adult cartoons as a kid, and how they just seemed weird and disturbing, and now I'm an adult and I still feel that way.