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Misery, what we now call depression, is the way your brain is telling you to make significant changes in your life. So many people in the modern age are depressed because the modern world is dreadful. There's a reason why 100 years ago when patients told their doctors they were miserable, the doctors would usually just prescribe they spend some time in the countryside, eat better and do more exercise... obviously that doesn't always work but it's pretty damn effective.
Modernity, as a whole, is killing us.
