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Folate may also play a role in cancer reduction. An article in the American Journal of Clinical Nutrition noted that folate's possible cancer-reducing properties are likely linked to its role in the production of substances that silence cancer DNA. The study points out, however, that some research has suggested that in some cases high levels of folate could actually encourage cancer cell growth. The authors write, "Folate may provide protection early in carcinogenesis and in individuals with a low folate status, yet it may promote carcinogenesis if administered later and potentially at very high intakes."