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The fact that humans can still exist with 1/26th of their DNA missing is an absolute testimony to the robustness of the DNA.
People look at the 7600 megabytes of data in the DNA and say (but that must be all there is right). NO!!!! You forgot that the DNA is just a turing tape, the machine that reads that tape contains yottabytes of data in its protien folding paradigm. Making women the tree trunk, and men the gradient ascent step.
If the one with the downs syndrome is the girl, You've got a big bug in the yottabyte human factory factory, if you've got downs syndrome in the male, you've got a big bug in your 7600 megabytes of suggestions on what works and what doesn't.
The DNA is like teeth on a chainsaw blade, you can lose entire section of the chain and it still works.