>>23587168> While grapefruit is not psychoactive, it may affect the metabolism of certain opioids. Tramadol, oxycodone, and fentanyl are all primarily metabolized by the enzyme CYP3A4, which is potently inhibited by grapefruit juice[8]. This may cause the drug to take longer to clear from the body. it may increase toxicity with repeated doses. Methadone may also be affected[8]. Codeine and hydrocodone are metabolized by CYP2D6. People who are on medicines that inhibit CYP2D6, or that lack the enzyme due to a genetic mutation will not respond to codeine as it can not be metabolized into its active product: morphineWow, who woulda thought?
>good job with the PT thoughThanks, I was a pretty active person before the accident it’s been pretty hard adjusting back to a NEET-like sedentary lifestyle. Still I’m making good progress in my recovery. A human body is weird, like it’s capable of healing itself so that you can get better but at the same time punishes you for trying to do better.
