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It refer to people finally realizing that they should only care about their close ones and the local region in terms of people, while the rest of the world are NPCs as far as you are concerned from a realistic perspective. You dumb nigger.
It especially hits the Feminists and LGBTQP+BBQ hard because they think everyone in the world is responsible to them as a collective whole, when their existences are realistically irrelevant to the average person's limited lifespan, like NPCs in games.