>>19356754>AmyloidosisIn vitro studies have suggested the capability of curcumin or curcumin derivatives to significantly reduce the β-sheet content of the peptide in a time dependent manner, (40) destabilize (41) and disaggregate (42) preformed Aβ fibrils, block the toxicity of Aβ oligomers, (42) and disintegrate preformed tau filaments. (43) Furthermore, in vivo studies have suggested the ability of curcumin to reduce amyloid plaque burden, (42) reduce insoluble Aβ deposits, (44) and disassemble tau oligomeric structures. (45) Combined with its additional promising properties in the diagnosis, prevention, and treatment of AD (reviewed in ref (46)), curcumin can be considered a highly promising molecule for future investigation and improvement.
https://pubs.acs.org/doi/10.1021/acs.jcim.9b00561https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7585045/ Serratiopeptidase was found to be as effective as nattokinase (an enzyme shown to degrade amyloid fibroid)
Nattokinase,serrapeptase and curcumin might be helpful
