>>17915143It makes a great deal of sense.
Basically, women's sexual selection paradigms are not evolved to promote the perpetuation of civilizatio; rather, they are grounded in the human past, which was one of localized tribal conflict and extreme hardship.
If given the choice, women will argue in favor of being allowed to have lots of promiscuous sex in youth, followed by attempt at relationships in later life, which inevitably fail at very-high rates due to the physiological consequences for women of having sex with many partners (reduced pair bonding at the biochemical level).
As such, the comic is demonstrating that this woman is enjoying her youthful sexual exploration, and in the process ensuring she will never have a functional long-term relationship, thus the ghostly visage of that LTR prospect evaporates before her eyes - and, while many will claim otherwise, the vast vast vast vast majority of people, woman or otherwise, do not want to die alone, but that is exactly what awaits women who can no longer functionally pair-bond, because at that point, even if they are with someone, they're still alone. And the realization of that fact is what has her crying in the last panel.
Pretty easy to understand desu senpai, especially compared to things like a demisexual transman explaining why nutting balls-deep in 'his' pussy is actually gay.
