https://www.drugabuse.gov/news-events/nida-notes/2016/09/regular-marijuana-use-associated-differences-in-brain-gray-matter-connectivity >A NIDA-funded brain imaging study has shown that regular users of marijuana have less gray matter than nonusers of the drugin the orbitofrontal cortex (OFC), a brain region that contributes to impulse control, decision-making, and learning. Such a deficit could make it more difficult to change counterproductive behaviors, including drug use.