>>21054481Ok. I'll try to explain it in a way that isn't full of useless jargon, but doesn't treat you like a retard. It's just kind of hard to figure out where to start, i don't know what your background knowledge is.
Lets break it down to 3 parts. A brief on how ageing works, then transposons and finally how these behave in men/women with age.
Cells ar made of lipids, proteins and DNA. DNA codes for proteins, proteins do and make everything including lipids and DNA replication. As we age DNA accumulates errors and loses its protection (telomers, shit at the two ends of DNA protecting it from falling apart). It also loses its tight control over what is and isn't made, this is rearangement of epigenetics (shit taht sits on DNA condensing and inactivating or loosening and activating it). Aging is a clusterfuck where everything causes and is caused by everything, but it starts with DNA errors, which fucks up epigenetics, which fucks up proteins, which fucks up everything else and you eventuall die.
One of the main reasons DNA gets fucked up is transposons, basically genes that don't do shit but replicate themsleves only. They copy and paste themsleves all around your genome. Why do we have these? Good question, fuck knows, we have some ideas but we aren't sure.
We have a shitton of transposons, and most are silenced where sperm is made, but we lose silening over time. Far, far less are silenced in oocyte (female egg). This means they accumulate mutations faster. For men, you are best before 40. For women you are best beofre 25. The damage accumulated in your soma (body not connected to reproduction) doesn't matter, worst can happen is cancer and death. The mutations accumulated in the germline (sperm or egg) get passed on, and if there is too much, enough to let the offspring survive, but full of disorers, well then you are fucked. Because those disorders become fixed in the population, and there will just be more and more.
If anything isn't clear, ask..
