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>Heavy, long-term use of cocaine, meth, and bath salts causes irreversible brain damage, including dopamine system depletion leading to severe cognitive deficits, chronic psychosis, and treatment-resistant depression. Cardiovascular strain from both drugs results in accelerated heart disease, hypertension, aneurysms, and a sharply elevated risk of sudden cardiac death or stroke. Polysubstance users often face multi-organ failure, extreme weight loss, and a reduced life expectancy of 20-30 years, with many effects persisting even after quitting.
