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Ironically Girls Last Tour depicts such a cataclysm
that's why it's really a great piece of art
A man's existence at the end of the human world is a joke: how is he meant to establish his will against the full might of nature and impending doom?
A woman's existence in that context is more fitting. Isn't the end of one thing pregnant with the potential of the birth of new things in the future? All the side characters try to act like men, even the women.
But the two girls born after the downfall of technological civilization are the perfect picture of mankind in the face of awesome superhuman power. They are really women in a way nobody else was capable of being.
Man is a warrior and conqueror in the face of other men, and in the face of everyday nature. But in the face of a cataclysm or of divine wrath, what manner of conquest can he genuinely pursue? In the face of even the technological civilization he himself creates he is reduced to a parody of himself.
The setting has men who did what they should have in fighting the wars that wrecked their evil world. Those men could transcend in death.
The girls also transcend; seeing everything that is common in conditioned material existence they are finally capable of letting it go. But they had to be girls. For men to do that is emasculating. He should fight to the end.