Fun fact: the CB1 receptor that is responsible for the feeling of being high also occurs during brain damage. So when you smoke marijuana you simulate brain injuries.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3138655/>Paranoid Schizophrenia is Characterized by Increased CB1 Receptor Binding in the Dorsolateral Prefrontal Cortexhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034083/>In humans, mounting evidence shows that CB1 receptor densities are altered in schizophrenia