Quoted By:
ONE COMPLICATING FACTOR IN DESIGNING SUBUNIT VACCINES TO ASFV IS THAT CERTAIN ANTIGENS, OR COMBINATIONS OF ANTIGENS, CAN INDUCE ENHANCED DISEASE IN SWINE THE MECHANISM(S) AND THE INDIVIDUAL ANTIGENS RESPONSIBLE FOR THE VACCINE-INDUCED ENHANCED DISEASE ARE UNCLEAR, BUT DNA VACCINATION EXPERIMENTS SHOWED A CLEAR LINK BETWEEN THE INDUCTION OF ANTIBODIES TO THE CP204L, E183L AND EP402R FUSION PROTEIN AND ENHANCED DISEASE. HOWEVER, EXPERIMENTS WITH LIVE ATTENUATED VIRUSES SUGGEST A ROLE FOR BOTH HUMORAL AND CELLULAR RESPONSES IN PROTECTION AGAINST VIRULENT STRAINS OF ASFV AND THEREFORE A SUBUNIT VACCINE MAY NEED TO INDUCE BOTH ARMS OF THE IMMUNE RESPONSE FOR EFFECTIVE PROTECTION
