>>11810133Too much alcohol overtime can reduce the total number of GABA receptors in the brain. Since GABA, the main inhibitory neurotransmitter counteracts glutamate, the main excitatory neurotransmitter, it is possible to develope a strong tolerance to alcohol which can result in a large build up of glutamate in the brain AKA a “glutamate storm”. This can result in excitotoxicity and symptoms range from seizures, hallucinations and coma all the way to total and irreversible brain death.
