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My little pony has more action and adventure than your average moe show. The characters in MLP frequently have conflict either external (a monster attacking the ponyville) or internal (a pony is stressed out about not being able to pass a test, friends have a problem ect) wheras moe shows are often comedic and have very little conflict. MLP has a moral message to a lot of its episodes whereas Moe shows do not. MLP has antagonists to the main characters and there are high stakes to some episodes (generally the first and last episodes). MLP and moe are completely different genres that have very little in common.
