>>22570504Not sure, I grew up painting cars at a young age so it's possible I was exposed to chemicals.
>Biopsy reportMICROSCOPIC DESCRIPTION
H E stained sections reveal lymph node tissue with focally preserved
follicular architecture. Follicles and mantle zones are not
well-defined and difficult to appreciate on the H E stain. The
interfollicular area shows a mixed population of small lymphocytes.
Blood vessels are unremarkable. The sinuses are patent, containing
histiocytes and plasma cells. There is no necrosis, granulomas, or
metastatic cells present.
MICROSCOPIC DESCRIPTION (Continued)
Immunohistochemical stains:
CD20 and CD79a highlight small B-cells in a diffuse proliferation
throughout the biopsy specimen, at least as numerous as T-cells.
CD5 and CD43 appear to show abnormal co-expression in B-cells.
CD3, CD5, CD43, and CD7 shows pleomorphic small T-cells in the
interfollicular areas with no loss in marker expression.
T-cells show a normal CD4:CD8 proportion of 4-5:1.
BCL6 highlights B-cells in a rare involuted germinal center that is
negative for BCL2.
CD21 and CD23 highlights a few small intact follicular dendritic cell
meshworks that lack germinal center B-cells.
CD23 also highlights scattered B-cells in the interfollicular areas.
Ki-67 highlights a rare involuted germinal center, as well as
scattered lymphocytes in the interfollicular region.
Negtative stains: cyclin-D1, CD1a, TdT, CD10.
