>>5346987Dog breeder here and I have a few friends that are mixed so the data concurs with humans.
Mixing genetically diverse strains of DNA has a degree of unpredictability, often times removing certain information strains that allows animals to function as they naturally evolved to.
Instincts might be bred out or their might be contradictory neural synapses, different dogs have more active parts of the brain compared to others due completely to instincts.
Think about the brain like a fine walked path through the brush, it's easy to get to a place frequently walked through, it's been worn.
Dogs evolved like this to be more receptive to certain instincts, it's a lot easier to train a bloodhound to hunt down scents than a pug.
This is why pitbulls are abhorrent, they were mixed very egregiously because their longevity as a breed wasn't desired, and because of that irresponsibility, they cannot be easily trained to function like other dogs, often you can only get them to imitate other dogs is through food dependency, which is a bad trait in domestication.
Humans are no different, the different sub species evolved differently, especially due to ancestry, Africans have almost no neanderthal DNA, which is the DNA line that spawned winter preparation agriculture which led to oral history to be taught down, education and literacy.
African evolution did not require this, which is why it took them so long to develope literacy, the Zulu empire only found a need for a dictionary once they actually had things to teach people, and even then, there are significant things Africans do not have a word for, like promise, that cause moral issues when they are in other societies that have a need for such things.
Mixing genealogies is unpredictable, and from most observed cases, mixed people have huge depression, suicide and mental health concerns, as well as physical health issues like being unable to receive bone marrow from their parents.