You Can't Kill What Isn't Alive
Prions cannot be destroyed by boiling, alcohol, acid, standard autoclaving methods, or radiation. In fact, infected brains that have been sitting in formaldehyde for decades can still transmit spongiform disease. Cooking your burger 'til it's well done won't destroy the prions!
The Controversy Behind Prions
The idea that a protein alone could transmit disease has been around since the 1960s. New evidence has been stacking up to support this idea ever since.
Ever since Stanley Prusiner coined the term prion in 1982 and showed that purified prions can transmit spongiform disease, skeptics have been trying to prove him wrong. The idea that a protein can reproduce itself without going through a nucleic acid intermediate goes against everything we know about transmissible diseases. Even the simplest viruses contain genetic material, DNA or RNA, that codes for proteins necessary for function and transmission. Because prions appear to be infectious proteins that can self-replicate, the central dogma of molecular biology, (DNA to RNA to protein) seems not to apply here. So maybe these scientists are right to be skeptical. Below are some of the reservations skeptics have about the protein-only hypothesis.
The strain phenomenon
Scrapie and other spongiform diseases come in distinct strains that differ in their incubation period, symptoms, and effects on different brain regions. Skeptics argue that these differences are due to mutations in nucleic acid and is evidence that prions do indeed have genetic material.
https://learn.genetics.utah.edu/content/basics/prions/ 
