Two patients, in whom POIS was suspected to be caused by auto-immune reaction to their own semen, were successfully treated by allergen immunotherapy with their own autologous semen. They were given multiple subcutaneous injections of their own semen for three years.[1] Treatment with autologous semen "might take 3 to 5 years before any clinically relevant symptom reduction would become manifest".[1] A case report used a technique known as "Intralymphatic Immunotherapy", the treatment has been successful in improving 60-90% of symptoms. The patient received only five injections of the autologous semen using this technique.[18]