>>9903684I like this study from the bits I've read. Here is the conclusion:
"Overall, our data suggest that it is unlikely that the terpenoids studied here affect Δ9-THC interactions with cannabinoid receptors. However, this is not a definitive rebuttal of the entourage effect. Our study cannot address the possibility of entourage effects emerging through effects of terpenoids on cannabinoid metabolism and distribution as well as interaction with other G-protein-coupled receptors, ligand-gated ion channels, signaling cascades present on the same cells that express cannabinoid receptors, or on other cells up or downstream of the cannabinoid receptor expressing cells. There are many other ways that these molecules could interact with cannabinoids to influence the overall therapeutic and subjective outcomes of cannabis administration, and it should be acknowledged that Δ9-THC influences signaling at a wide variety of other noncannabinoid receptor targets (see Banister et al.31 for a review). Terpenoids may even have primary effects on distinct functional modules that together with cannabinoid receptor-modulated pathways are ultimately integrated into a behavioral or physiological output. So the quest for entourage does not end here; in many ways, it has only just begun."
