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A virus mutates girls into catgirls and brainwashes guys into their servant drones.
The catgirl spreads it with a bite that injects a strong cocktail of paralyzing agent, aphrodisiac, psychoactive, and mutagen. Sinking her teeth into an artery can produce a new catgirl or a slave within a minute, whereas a victim escaping with a bite on the leg will change slowly over a few hours.
On most girls, the ears shift upward into triangles, and the coccyx extends to about arm's length. The ear and tail fur depends on which type of cat the girl matches best (e.g. shy and polite = house cat; strong and outgoing = wild cat). Teeth and nails grow longer and sharper, and eyes get slit pupils and reflective inner coating. Brain function is moderately to heavily altered, replacing human speech and behavior with feline sounds and instinct. The heart grows tougher and faster which raises normal body temperature and eliminates the need for clothing.
A slave boy is utterly infatuated with the catgirl who bites him, putting her health and pleasure first and attending to her every need. A bite from another catgirl may either convert him or paralyze him with indecision, but will almost certainly start a catfight.
Superior constitution and intellect can grant some resistance to these changes.
A girl under 15 or so typically does not produce sufficient hormones to fuel the mutation. The bite only alters her mind, as it would a male, except the catgirl takes her as a little sister, a higher class of servant who receives care and feline training until her own transformation occurs sometime during puberty.
This is all assuming you're judged worthy to join or to serve (mainly on looks, youth, and fitness). If a catgirl doesn't wish to turn you, you are food and/or fair game.
The result? Of course, civilization gone, remnants of humanity constantly battle against an ever growing and evolving horde, drama of loved ones turning into them, allegory for human society, etc.
