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The first thing that needs to go is the long chain.
The second thing is the assymmetrical wheel size and ultra long wheel bases.
Inevitably one ends up with a MBB or a FWDRWS recumbent.
Moving-bottom-bracket or
Front wheel drive rear wheel steering.
The cruzbike V20 is about the fastrst two wheeler there is at the moment
Pic is a rear wheel steering prototype
There was also a velomobile that used RWS. I forgot it's name. While it wasn't as aero as the current ones it worked really well and was quite fast due to the efficient drivetrain.
Any drivetrain that requires pulleys/bent angles in my opinion should be removed from the drawing table.