>>1186091>>1186093If you have the money to spare, sure, but honestly it's not really worth it IMO, I doubt you'll notice any difference at all. Plus any groupset replacements you have to make in the future (and you will have to) will be more expensive too, so take that into consideration. I'd go with the 105 and use the rest of the money on good tires.
Look and Shimano cleats are different and not compatible between each other
You can get plastic flat pedal covers for clipless pedals to use with regular shoes
And no, single sided road shoes aren't a "meme". The other anon is just too dumb to use them. They feel great.