>>1027236Some places more than others. For example, riding any distance on I-90 outside of Boston would probably get you killed, a ticket or both. In general, using interstates (or other big roads) near big cities where you're going to be riding with a lot of traffic is a terrible idea and often illegal.
However, riding 10 miles on I-94 outside of Teddy Roosevelt National Park (the middle of nowhere) where there are no paved alternatives seemed to be okay. There wasn't much traffic, people I asked beforehand told me to go that way and the police car which passed me didn't stop. The other occasion was crossing the Colombia on I-90 which is also pretty far into the middle of nowhere.