>>1143830It's theoretically possible.
The Airbus A380 already exists, and while it's selling poorly right now, the main issue is the cost of the aircraft itself. Airlines stuggle to make it profitable, not due to the engines burning so much fuel, but due to the overall cost of the aircraft being so high.
Making an A380 be a twinjet instead isn't as far fetched as you might imagine though. Airbus has already made the Airbus A300-600ST also known as the Beluga. That thing can only get to Mach 0.6 due to the aerodynamic design, but it still can carry the entire fusilage of an Airbus A320 inside it. The Beluga is a twinjet, so there's not concerns about takeoff weight there.
The Beluga XL (A330-200ST) will be a larger supertransporter for Airbus, and it too will be a twinjet using RR Trent 700 engines.
The main issue which probably is inherrant, is that these supertransporters don't have fantastic range. They can fly transatlantic fine, but only to the US east coast. More inland to airports in Texas or to the west coast, and these aircraft will be needing technical stops.
More engines usually means more range, though the Boeing B777-600ER manages that fine with its engines, and the Airbus A350-900 also can do the range thing with 2 engines also.
