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Little evidence that chemical imbalance causes depression, UCL scientists find

No.1074680 View ViewReplyOriginalReport
Researchers question use of antidepressants, prescribed to one in six UK adults

https://www.theguardian.com/society/2022/jul/20/scientists-question-widespread-use-of-antidepressants-after-survey-on-serotonin

tl;dr:

>Scientists have called into question the widespread use of antidepressants after a major review found “no clear evidence” that low serotonin levels are responsible for depression.
>Millions more people around the world regularly use antidepressants.
>“Many people take antidepressants because they have been led to believe their depression has a biochemical cause, but this new research suggests this belief is not grounded in evidence,” said the study’s lead author, Joanna Moncrieff, a professor of psychiatry at University College London and consultant psychiatrist at North East London NHS foundation trust.
>“Thousands of people suffer from side-effects of antidepressants, including the severe withdrawal effects that can occur when people try to stop them, yet prescription rates continue to rise.
>We believe this situation has been driven partly by the false belief that depression is due to a chemical imbalance.
>According to the research, there is also evidence from other studies that antidepressants may actually induce low serotonin in the long term.