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Just left a job that was ~75% invasive plant control. I've seen every weed in the eastern US and without a doubt kudzu is the worst. Things like Tree of Heaven, garlic mustard, and bush honeysuckle can be really problematic, but nothing comes close to the sheer destruction that can be unleashed by a patch of kuzdu left unchecked. This stuff will readily kill trees and even if you successfully kill every living vine, there are a thousand underground tubers ready to sprout and wreak havoc all over again come spring. Pic related is me on an ongoing kudzu removal job spraying some mean herbicides on a 30 acre kudzu wasteland with the hope of it translocating into the tubers.
