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Speaking as someone who has been on a 600 mile bike tour I found that the wrong handlebar setup will cause you enough pain to break you down and take a bus ride home. Absolute showstopper.
I refuse to ride a multi-day ride without a bar setup similar to this:
Flat bars with an 11 degree sweep
Profile Design long bar ends with the sideways hand position and the forward position
It's something you can only find out through a long trial-and-error process, but you simply must have multiple ways to rest your hands on a bike because any position will get uncomfortable after a while.