>>2280680A centerfire .22 will work. A.22 lr could kill one, but if you gotta ask, you couldn't do it. If I had a reason for a north American big cat gun, I'd go up to 6 or 7mm. Not because it might run both ways, but because a wounded cat is a dangerous and cats are hard to kill.
Col Jim took out dozens of maneaters with a .275 (roughly equivalent to a 7x57) but he only took head shots and was all cool an' shit.