>>1018881You better believe it. Here's an extract from “Notes on Arrow Wounds,” J. H. Bill, American Journal of Medical Sciences, 1892. The full journal article contains several accounts of frontiersmen dying gruesome deaths from Indian arrows.
I always chuckle when someone gets shot with an arrow in a movie, and keeps fighting or otherwise moves in any way. You get hit with one of these, and you're going to pretty much stay where you are, immobile.