>>2535572>>By autosomal DNA, Ötzi is most closely related to Southern Europeans, especially to geographically isolated populations like Corsicans and SardiniansSee pic related.
The Original Sardinian language is lost to history. But it probably was in the proto-basque family as they both seem to have come from the same place genetically.
Best bet for Ötzi is proto-basque.
The distance between the basque country and Tyrol is less than many American Indian language ranges.
Take the Paiute. Who's language group reached from Arizona to Oregon. And belonged to the Aztec language family, which stretched from central Mexico, all the way to the Canadian border.