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Bodybuilders get knee and spine issues from lugging around extra muscle mass beyond their natural weight, so do fatasses.
Human body is very finely tuned for walking with its optimal BMI. Add more than, say, 10% of that weight and you're setting yourself up for grinding cartilage, inflamed joints, etc. Add uneven terrain and massive torque from any slip, plus the fatigue increasing your chances of fucking up, and the imbalance and weird posture from a huge sack hanging off you (boys, I'm talking about a different sack) and you're quickly going to learn why old people often hang up their hiking packs despite wishing they could get out there.
Pack light, keep it simple. Lighter gear doesn't have to be expensive and taking scissors to your kit is free.
