>>1499685>Mississippi River is second-most polluted U.S. waterway. More than 12.7 million pounds of toxic chemicals such as nitrates, arsenic, benzene and mercury were dumped into the Mississippi River in 2010, according to a report released today by the advocacy group Environment Missouri.oh yes the mississipi, one of the most heavily polluted systems of earth, I'm sure that doesnt contribute at all to a hardy bottom feeder exploding in population...