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A rifle gives you better accuracy, but a 22 is only good for small targets. Small game usually only presents shots at less than 25 yards, so a rifle isn't necessary. You could do maybe 50 yards for a headshot on a deer under field conditions, but I could kill the same animal at the same range with my Glock 34 just as easily with a heart/lung shot. Obviously a headshot would make post-shot tracking easier, but this isn't a big enough advantage to justify the weight and bulk and expense and complication of a completely separate rifle system in addition to the Glock that I'm already carrying anyway. If I carry a rifle at all my takedown 9mm PCC is vastly more useful, and the extra weight is offset by the fact that it doesn't require an extra ammo supply. Carrying a rifle actually makes you a worse hunter because you have to carry it with a sling, so you don't have both hands free to use a walking stick for balance and precise foot placement, for using trees for support, and gracefully clearing obstacles, so you're going to be louder and clumsier carrying a rifle. Both the 22 rifle and the Glock give you about 50 yards on a deer but the rifle will make it harder to get there.