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This is my current lineup:
>older model Osprey Atmos 65L
>Kestrel 48L
>Patagonia Ascensionist 25L
>Daylite
I don't backpack but I need a large pack for my dayhikes as a park ranger. I generally use the Atmos in the Summer since it's got the best weight distribution (although the cushioning is completely worn out on mine) and it's when I have to carry the most gear, usually in the 40-60lb range.
I switch to the the Kestrel during winter patrol or if I have an easy day during the warmer seasons.
I use the other two packs as daypacks. The Patagonia one was kind of a vanity buy but it's a nice lightweight pack. I use the Daylite more often especially if I'm going trailrunning since it has a nice snug fit.
Will answer any questions about these or similar packs.