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Honestly, the most important thing is to have like-minded friends. Even the greatest operator of all operators has to sleep. In a post-apocalypse situation, a dedicated group of friends who plan to survive together and who really love each other is the best defense you can have. It's too much work to live alone when you're not leeching off the edges of a civilization, and the margins for error are too thin.
So yeah, learn how to sustainably farm, buy a gun, get some land, put your BOB together, plan a route, but make sure you're maxxing your relationship stats first or you might as well have not even bothered with the other shit.