>>1512469Not state-wide,AFAIK, but there are specific water bodies (or areas) where the use of natural baits is restricted. Even then, I believe it's more common to see a "fly or lure" requirement rather than strict fly-only. AFAIK, those restrictions are more common out west than in the Northeast (in New York and New England, there are very few waters where natural bait is disallowed, except for anadramous salmon).
Most, if not all, states' Fish and Wildlife agencies have a website where you can find this kind of information. They usually have a "digest" in PDF form with all the relevant details, which you'll want to read if you plan to fish there.
Incidentally, states differ even in their definition of a "fly" vs. a "lure." Here in Vermont, a fly can have a maximum of one, single-pointed hook, and no more, while next-door in New York, it's still only a single hook, but it can be double. In either of these states, more than one hook (and in Vermont, more than one point) makes it a lure, not a fly, as does the addition of spinners or such, so spinner-flies (like "Joe's Flies") and tandem-hook streamers are legally lures, not flies. As I said, there are few if any waters here that are strictly fly-only, rather than fly/lure-only, but the distinction still matters because of the regulations about how many you can have on a line (e.g., in Vermont, you can have up to three flies on one line, but no more than two lures).