>>182358That depends on your preferences, but you can weed out regions by climate, nature, population density, population growth, economic growth, common industries, cost of living adjusted income, unemployment, voting behavior (read: dominant political views), legal situation (read: prevalence of overly regulatory lawmaking), percentage of certain ethnic groups if you're that kind of person, religion, air quality, the choice is yours. I suggest the maps and to some extent the forum at
city-data.com for any more specific research, and of course you can easily google any particular topic, and there are plenty of sources ranking cities and metro areas in the US by various aspects of perceived living quality on an annual basis. And simply google pictures of a place.
Of course you're most likely not gonna find the perfect area for you, but some research can really help you along the way.
