Terence McKenna was the hippie who popularized mushrooms in the west. He may have been the guy who discovered ayahuasca and introduced it to the west.
We wrote a book on how to grow mushrooms, which are legal in some places in the US: Psilocybin: Magic Mushroom Grower's Guide. And I know for a fact he’s mentioned plants in the US that ayahuasca could be derived from (these are sometimes called “pharmahuasca”).
There are also frogs. The Colorado River toad is legal to own as a pet, but produces a poison that’s a controlled substance. Supposedly the natives would spread the poison on a rock, allow it to dry, then scrape it off and smoke it. I think modern druggies use a piece of glass rather than a rock, and I think it’s incredibly dangerous (and definitely illegal). But again, the frogs are totally legal and pretty hardy, so they’re easy to keep as an exotic pet.
>>2728460Lol.
OP did ask for legal substances, though. Peyote is not only illegal, but it has some kind of federal protection due to its vulnerable status (I don’t think it’s endangered; maybe threatened?).