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Vuescan gives comparatively sharper images than Silverfast. Also Silverfast requires you to buy a new license for each scanner, Vuescan works with any scanner on a single license.
IMO the UI on Vuescan is much simpler, Silverfast is pretty cluttered with stuff you don't need.
You should be scanning your images by locking a film base exposure and capturing the widest dynamic range from dark to light. Do any negative conversations afterwards in Photoshop preferably with Colorperfect for best results.