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I play on full manual all the time so I'm usually pumping ISO up so that I can stick around 1/100 which I'm pretty comfortable hand holding any subject I usually shoot.
If that means Sunny 16 1/100 iso 100 great, if it means I need to push her to 2.8 1/100 and iso 3200 when I wasting space in parking lots with the buds at midnight than so be it.