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Depends on where your pictures end up on. All of my pictures end up on web or Facebook, where they are compressed to shit. So medium format makes no sense. However having more information and pixels to work with in postprocesing is an advantage, not big enough for me, but it may be big enough for others.
For someone who spends a lot of time crafting and photoshoping one master crafted image it makes sense. I played around with sony a7rII and fuji GFX raw files, and it seemed like i can push out more quality out of Fuji files, they were more flexible, and the end result was better. However its probably not worth the bother for 95% of photographers, when people look at instagram photos on their phones mostly.
