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There was once this (now cancelled) isekai manga about a guy who wants to get revenge on a bunch of parodies of well known isekai characters. I'd adore to do a version of this where you're some Agent 47-esque assassin that needs to infiltrate an inter-dimensional party filled with all kinds of people and creatures from different worlds and assassinate some targets, but the problem is that every world has their own magic system/technology/other shenanigans so you need to play around those worlds' rules to figure out a way to kill the target effectively and hide the bodies without being found out instantly.
My main issue with this idea is that it would require either a LOT of pre-quest world building on my part or I would have to just straight up rip off systemms and characters from other series which would make me feel kind of disrespectful. I also think this idea would work better with multiple authors for the aforementioned pre-quest worldbuilding to make each world feel more varied and different.
This is all just a pipe dream though cus realistically /qst/ would refuse to kill the waifus and softlock the game.