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Even if we arent aware of the Warp Gate that would cut our travel times to the eastern Galaxy in half (very useful for the Rangdan War) there are IC things there we could likely be aware of to have reasons to go there.
The famed Lathe forge worlds and the Cult of Sollex. Finest laser Smiths in the galaxy unchallenged. A tempting thing given our love of Lances both on knights and ships.
Calixis is also the home of the Cult of Myrmidon, the best combat techpriests in the galaxy who specialize in warfare and can fight in melee and wield heavy weapons to boot. These guys are comparable to space marines iirc.
